What is PLGA CAS 26780-50-7?

PLGA CAS 26780-50-7 is a copolymer with no functional side groups formed by the polymerization of lactic acid and glycolic acid, and is an important class of biomedical polymer materials. It is a crystalline light yellow or translucent solid particle, or an off-white powder.

PLGA has good biocompatibility, non-toxicity, good capsule and film-forming properties, and is widely used in pharmaceuticals, medical engineering materials and modern industrial fields. Its degradation products are lactic acid and glycolic acid, which are also by-products of human metabolic pathways.

Uses of PLGA CAS 26780-50-7

PLGA CAS 26780-50-7 has a wide range of uses. It is widely used in surgical sutures, anti-adhesion membranes, tissue engineering scaffolds, biomedical fields, fracture internal fixation materials, tissue repair materials and drug controlled release systems.

In terms of drug controlled release system, PLGA microspheres can steadily release GM-CSF during the release process, and GM-CSF-DEX particles can effectively protect the biological activity of GM-CSF in the microsphere system, while achieving steady sustained release for more than 4 weeks. The drug sustained release behavior of the coating is optimized by assembling PLGA-PEG-PLGA copolymer nano-micelles. After assembling PLGA-PEG-PLGA drug-loaded micelles into the mineralized collagen coating to obtain the mineralized collagen/PLGA-PEG-PLGA copolymer coating, the drug sustained release ability of the coating is effectively optimized, the initial burst release is weakened, and the later sustained release time is prolonged.

In addition, PLGA-PEG-PLGA thermosensitive hydrogel can gel in situ and release growth factors at fixed points after implantation in the body, and can provide a microenvironment suitable for the growth and differentiation of ADSCs. The hydrogel complex of PLGA slow-release microspheres carrying ADSCs, SDF-1 and IGF-1 can effectively promote the regeneration of cartilage tissue, which is very suitable for cartilage tissue engineering research and should have great application prospects in clinical research on cartilage repair. PLGA microspheres can steadily release GM-CSF, and their thermosensitive hydrogel can promote the regeneration of cartilage tissue.

With the continuous development of the biomedical field, the market prospects of PLGA are very broad. At the same time, our company is also constantly innovating technology and optimizing products to improve the performance and quality of PLGA and meet the diverse needs of the market. If you have purchasing needs, please contact us.