Poly(D,L-Lactide-Co- Glycolide) PLGA CAS 26780-50-7, PLGA, is a copolymer which is used in a host of Food and Drug Administration (FDA) approved therapeutic devices, owing to its biodegradability and biocompatibility. Unilong Group specializes in the research, development, production and operation of biological materials and green solvents. It is a high-tech enterprise integrating the research, development and production of new environmentally friendly and degradable materials.
Unilong can provide PLGA polymers of various specifications and proportions, including PLGA(50/50), PLGA(65/35), PLGA(75/25), PLGA(85/15), PLGA(95/05). Different monomer proportions can prepare different types of PLGA, for example, PLGA 75/25 indicates that the polymer is composed of 75% lactic acid and 25% glycolic acid.
PGA, PLA, and their copolymer PLGA are linear aliphatic polyesters that have been shown to be biocompatible and degradable in non-toxic components with controllable degradation rates in vivo. These polymers are degraded by hydrolyzing ester bonds, and the degradation products are eventually excreted as CO2 and H2O. PLGA is one of the few synthetic polymers that has been FDA-approved for human clinical use. The antibacterial absorbable medical suture used in clinic is made from the copolymerization of polylactic acid monomer lactic acid and glycolic acid.
PLGA is often used as a raw material for tissue engineering scaffolds. The electrospun fibers prepared by PLGA were studied. It was found that the morphology and structure of the electrospun fibers were similar to that of natural extracellular matrix. The prepared PLGA electrospun fiber has a porosity of more than 90%, and most of the pore sizes are in the range of 25~100um, which improves the cell permeability of the material, provides more structural space for cell growth, and is conducive to the nutrient exchange and metabolism between the scaffold and the environment. It is an ideal scaffold material for tissue engineering. PLGA has good biocompatibility and biodegradation performance and the degradation rate is controllable. It has wide application of PLGA in biomedical field. At present, it has been made into artificial catheter, drug sustained-release carrier, tissue engineering scaffold material, skin transplantation, wound suture, implantation in vivo, micro-nano particles and so on.
Polymers were first introduced three decades ago as bioresorbable surgical devices. Since then, polymer-based nanoparticles have been extensively studied in a variety of fields. Amidst the various polymers synthesized for formulating polymeric nanoparticles, poly(lactic-co-glycolic acid) (PLGA) is the most popular. PLGA has several interesting properties such as controlled and sustained release, low cytotoxicity, long-standing biomedical applications, biocompatibility with tissues and cells, prolonged residence time and targeted delivery. Therefore, PLGA demand is growing, the prospect is very broad.
