‌Crospovidone with CAS 25249-54-1‌ is a water-insoluble synthetic cross-linked N-vinyl-2-pyrrolidone homopolymer, also known as cross-linked polyvinylpyrrolidone (PVPP). The chemical name of crospovidone is 1-vinyl-2-pyrrolidone homopolymer, and the molecular formula is (C6H9NO)n. Due to the water insolubility of the material itself, the exact molecular weight has not been determined, but it is usually greater than 1,000,000. Depending on the degree of cross-linking, cross-linked povidone can appear as a super absorbent resin (low degree of cross-linking), a hydroabsorbent gel (medium degree of cross-linking) or an insoluble substance (high degree of cross-linking). Compared with water-soluble polymer PVP, PVPP can only swell but not dissolve in water.

Cross-linked povidone has many excellent and unique properties, such as hygroscopicity, easy fluidity, insolubility in water, strong acids, strong alkali and general organic solvents. It also has strong swelling properties and the ability to complex with many types of substances. In addition, crospovidone also has good physiological compatibility and adsorption and complexation properties, has good tolerance to skin and mucous membranes, and has no teratogenic, mutagenic or carcinogenic effects. These properties make crospovidone widely used in many fields.

‌Crosspovidone has a wide range of applications, covering many fields such as medicine, cosmetics, food, new energy, etc. It is an important pharmaceutical excipient‌

In the pharmaceutical field, crospovidone is mainly used as a disintegrant for tablets, which can quickly absorb water and swell, promote the rapid disintegration of tablets or capsules, and facilitate the release and absorption of drugs. In addition, it can also be used as an adsorbent and carrier to improve the stability and bioavailability of drugs; in suspensions and ointments, crospovidone can increase the viscosity of the system, improve the stability of the suspension, and prevent the drug from Sedimentation; as a filler for tablets and capsules, it increases the hardness and brittleness of tablets and reduces the weight difference of tablets; by adjusting the molecular weight, cross-linking degree and other properties of cross-linked povidone, it can be prepared with controlled release and Drug preparations with sustained-release effect, extending the action time of drugs.

In the field of cosmetics, crospovidone is widely used in the pharmaceutical industry, medical devices, and membranes due to its excellent oil-water amphipathic properties, good chemical stability, extremely high biocompatibility, and strong affinity with hydrophobic substances. Industry, new energy battery industry, nanomaterial preparation and other fields‌.

Crospovidone also plays an important role in food processing, for example in personal care products, toothpaste, detergents, optical and electrical applications, papermaking, printing and dyeing, coatings, inks, fiber and textile materials, ceramics, metal coatings , photolithography and photography, metallurgical quenching fluids and cutting fluids, drilling and completion fluids, natural gas transportation and other fields are used‌.

In addition, crospovidone is also used in ophthalmic preparations, such as eye drops and eye ointments, to increase the viscosity and retention time of the drug and improve its efficacy‌.

To sum up, the application of crospovidone is not limited to the pharmaceutical field, but also extends to many fields such as cosmetics and food processing, demonstrating its multifunctional characteristics‌.