Copovidone VA64 is a kind of very important medicinal materials, it is ‌1 – vinyl – 2 – pyrrolidone‌ and‌ vinyl acetate‌ in a ratio of ‌6:4‌ linear copolymers composed of (by weight). The CAS number is 25086-89-9. It is a water-soluble high-molecular polymer with excellent performance.

VA64 has many features and advantages. It has good solubility (water solubility and organic solubility), excellent film-forming property (transparent, tough and elastic), strong adhesion, certain disintegration, good plasticizing effect by itself, relatively stable physical and chemical properties, good compatibility and high safety. Due to its good solubility, adhesion, film-forming property, compatibility and low toxicity, it is widely used in the pharmaceutical industry, cosmetics and personal care, food industry and other fields.

I. Film Coating

This is one of the most core uses of VA64. The coating film it forms is ‌transparent, smooth, tough, elastic and not prone to cracking ‌. Film coating ‌widely applied to tablets, pills and small pills (including enteric-coated coating, sustained-release coating and flavor masking coating).

II. Binder

In the preparation of tablets and granules (especially wet granulation and dry granulation), VA64 is a highly efficient dry binder ‌or ‌wet binder ‌. It has strong adhesive power, which can effectively improve the compressibility of particles, increase the hardness of tablets and reduce their brittleness. It is commonly used in the ‌direct tablet press process.

III. Solid Dispersion

VA64 is a key carrier material in modern pharma preparations used to enhance the solubility and bioavailability of poorly soluble pharmas‌. It can wrap or disperse pharma molecules in its polymer chain by forming an ‌ amorphous solid dispersion ‌, prevent pharma crystallization, and greatly increase the dissolution rate and degree of pharmas in body fluids.

IV. Disintegrant

Although it has strong adhesive force, VA64 itself also has a certain disintegrability. In tablets, it can quickly absorb water and expand, promoting the disintegration of the tablets. It is often used in combination with other disintegrants.

V. In the Field of Daily Cosmetics

The PVP-VA series serves as a film-forming agent and styling agent. The higher the proportion of vinyl acetate, the lower the hygroscopicity, and it is suitable for mousse, hair spray and hair setting liquid.

VI. Other Industrial Uses

As a thickener and protective colloid for various inks. The water-soluble PVP-VA64 series products are also commonly used emulsifiers and protective colloids for plant protection agents, and can also be used as adhesives for coatings.

VII. Conclusion

The core value of copolymer VA64 lies in its versatility and high compatibility: in the pharmaceutical field, it is a key excipient for improving the performance of pharma formulations. In the field of daily chemicals, it can balance the functionality and safety of the products. At the same time, its low toxicity and easy processing characteristics also make it irreplaceable in fields such as food and coatings.