Polyvinylpyrrolidone (PVP) with CAS 9003-39-8 is a pharmaceutical excipients, high molecular compound with good biocompatibility and chemical stability.

PVP is a white to milky white powder. Easily soluble in water, alcohol, amines and halogenated hydrocarbons, but insoluble in acetone, ether, etc. It has excellent solubility, biocompatibility, physiological inertness, film-forming properties, film protection ability and the ability to combine various organic and inorganic compounds, and is relatively stable to acids, salts and heat. Therefore it has a wide range of uses. It has been widely used in the field of medicine, mainly including the following aspects:

As a Carrier

Improve solubility: Many drugs have poor water solubility, affecting their bioavailability. PVP can form complexes with drugs, increasing the solubility of drugs in water. For example, the solid dispersion formed by the insoluble drug griseofulvin and PVP can significantly increase the dissolution rate of griseofulvin in water, thereby improving the absorption efficiency of the drug.

Control release: PVP can control the release speed of drugs by adjusting its own concentration, molecular weight and other factors to achieve slow release or controlled release of drugs. For example, PVP and some antibiotics are made into sustained-release preparations, so that the drug is slowly released in the body, prolongs the action time of the drug, reduces the number of doses, and improves the medication compliance of patients.

Improve stability: Some drugs are prone to degradation, oxidation and other reactions during storage or use, resulting in reduced efficacy. PVP can interact with drug molecules to form a protective film that prevents the drug from contacting with oxygen and water in the external environment, thereby improving the stability of the drug. For example, some vitamins, combined with PVP, can effectively prevent its oxidation deterioration.

As pharmaceutical excipients

Tablet binder: In the tablet preparation process, PVP can be used as a binder to bond the drug powder together to form a tablet with a certain hardness and strength. It can increase the viscosity of the particles, make the tablets less prone to problems such as fragmentation and loosening during the tablet pressing process, and also improve the disintegration and dissolution performance of the tablets.

Coating material: PVP can be used as coating material to coat tablets, pills, etc. The coated drug can cover up the bad odor of the drug, prevent the drug from being released in advance in the stomach, reduce the stimulation of the drug on the gastric mucosa, and also play the role of moisture-proof and light-proof to improve the stability of the drug.

Suspension aid and thickener: In some liquid preparations, such as suspension, emulsion, etc., PVP can be used as a suspension aid and thickener to increase the viscosity of the liquid, so that the drug particles are evenly dispersed in the liquid, prevent the precipitation of the drug particles, and improve the stability and uniformity of the preparation.

In all, PVP is widely used in pharma field and is an important pharmaceutical excipients in the world. Unilong, engaged in PVP products. We can supply different grades of PVP products including Industrial, Pharmaceutical, cosmetic grade, etc. to meet your different applications.