PVPP with CAS 25249-54-1 is white or off-white hygroscopic and easy-flowing powder, odorless or slightly odorless. Insoluble in water, alkali, acid and common organic solvents. It has strong swelling properties and complexing ability with polyphenols. Therefore, it is considered the first choice disintegrant for high-end tablet drugs. Especially suitable for the formulation of instant and chewable tablets.

PVPP (crosslinked polyvinylpyrrolidone), as a commonly used disintegrant, has been widely used in pharmaceutical and other fields.

Application in tablets

Promote the disintegration of tablets: PVPP has a strong water absorption and expansion, can quickly absorb water when the tablet is in contact with water, and volume expansion occurs, so that the structure of the tablet quickly collapses and accelerates the disintegration process.

Improve tablet stability: PVPP can improve the hardness and brittleness of the tablet, in the process of tablet pressing, it can play a certain lubrication and bonding effect, so that the tablet in the storage process to maintain good physical stability, while not affecting its disintegration performance in the body.

Adjust the drug release speed: By adjusting the dosage and particle size of PVPP, the drug release speed can be adjusted. For some drugs requiring rapid action, increasing the dosage of PVPP or using a smaller particle size of PVPP can make the tablet disintegrate and release the drug faster; For some drugs that require sustained release, the amount of PVPP can be appropriately reduced or a larger particle size of PVPP can be used to make the drug release slowly.

Application in capsules

Help to disperse the contents: In capsules, PVPP can be used as an excipient to be mixed with pharmaceutical powder, etc. When the capsule enters the gastrointestinal tract, PVPP can rapidly absorb water and expand, help the drug powder in the capsule to disperse, and promote the dissolution and absorption of the drug.

Preventing drug aggregation: For some drugs that are easy to absorb moisture or accumulate during storage, PVPP can play a role in isolation and dispersion. It can be adsorbed on the surface of drug particles, prevent mutual attraction and aggregation between drug particles, and ensure the uniformity and stability of capsule contents during storage and use.

Application in granules

Improve the disintegration performance of particles: Adding PVPP to granules can make particles disintegrate rapidly in water to form a uniform suspension or solution. Improve the fluidity and compressibility of the particles: PVPP can improve the physical properties of the particles, increase the fluidity of the particles, and make it smoother in the packaging and production process. At the same time, it can also improve the compressibility of the particles, which is conducive to further pressing the particles into tablets or into capsules.

The application of PVPP as disintegrating agent is mainly relevant to its water absorption and expansion mechanism: PVPP has high water absorption, porous structure and strong expansion force. After absorbing water, isotropic expansion force is generated, which promotes rapid disintegration of solid preparation. Unilong is professional manufacturer of pvpp polyvinylpolypyrrolidone in China, engaged in the R&D, production and sales of PVPP. Unilong can supply Type A and Type B powder with high quality to meet your application.‌